P343 Combination vitamin supplementation therapy in children with cystic fibrosis

Pancreatic insufficient children with cystic fibrosis (CF) are routinely supplemented fat-soluble vitamins A, D, E, and K, serum vitamin levels checked in annual review assessments. Prior to 2018, the formulations involved preparations that provide Vitamin K separately, but A D together. This has proven be challenging for parents carers looking after young CF. Anew formulation (Paravit – CF), containing all required one easily deliverable format, became available, uncertainty remained as their efficacy maintaining healthy levels. study, temporally explored of this approach, comparing data from before supplementation. Royal Manchester Children’s Hospital (RMCH), a large tertiary CF centre northwest England, cares 330 CF, through direct input (200 children) by shared care arrangements (130 children). For under at RMCH, an electronic registry (THRIVE) captures anonymised pre- post-supplementation data, including anthropometric parameters. study growth parameters (weight, height, BMI) Paravit In preliminary analysis, complete was available on only 78 children. were slightly higher (p < 0.001), E lower = 0.027), group. No significant change observed Furthermore, stable. new supplementation program using single did not result loss attaining desirable Future research should explore parental satisfaction patient-reported outcome measures.